Related Experiment Video
Updated: Sep 9, 2025

Extraction of Non-Protein Amino Acids from Cyanobacteria for Liquid Chromatography-Tandem Mass Spectrometry Analysis
Published on: December 9, 2022
Protein activities driven by amino acid composition
Sean M Cascarina1, Eric D Ross1
1Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado, USA.
None:
A foundational concept in protein biochemistry is that the primary sequence of a protein determines its structure and function. However, some protein regions defy this constraint, with protein activity dictated more by amino acid composition than primary sequence. In this review, we examine the concept of "composition-driven protein activities." We discuss experimental criteria for classifying protein activities as driven by composition, how these criteria relate to primary sequence and composition, and how they have aided in characterizing existing examples of composition-driven activities. This emerging perspective provides a framework for thinking about the relationship between sequence and function in particular types of proteins.
More Related Videos
Related Concept Videos
Amino acids
What are Proteins?
Overview of Protein Metabolism
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Amino Acid Biosynthetic Pathways
Protein Folding
Amino Acid Catabolism

