Related Experiment Video

Updated: May 6, 2026

Laboratory Scale Production and Purification of a Therapeutic Antibody
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Laboratory Scale Production and Purification of a Therapeutic Antibody

Published on: January 24, 2017

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Optimizing colloidal stability and viscosity of multispecific antibodies at the drug discovery-development interface:

Vanessa Siegmund1, Daniel Klewinghaus1, Jonas Teroerde1

  • 1Early Protein Supply & Characterization, Merck Healthcare KGaA, Darmstadt, Germany.

Mabs
|September 1, 2025
PubMed
Summary

Optimizing multispecific antibodies involves addressing challenges like aggregation and viscosity. Aligning domain isoelectric points (pIs) improved colloidal stability and viscosity, enhancing antibody developability.

Keywords:
Antibody engineeringcolloidal stabilityformulationsin silico developabilityisoelectric pointmultispecific antibodiesviscosity

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