Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Organization01:13

Protein Organization

123.4K
Overview
123.4K
Protein Digestion01:02

Protein Digestion

86.5K
Protein digestion begins in the stomach, where the highly acidic environment can easily disrupt protein structure by exposing the peptide bonds of polypeptide chains. After polypeptide chains are broken into individual amino acids by a series of digestive enzymes, the amino acids are transported to the liver via the bloodstream to produce energy.
86.5K
From DNA to Protein03:06

From DNA to Protein

20.9K
The flow of genetic information in cells from DNA to mRNA to protein is described by the central dogma, which states that genes specify the sequence of mRNAs, which in turn specify the sequence of amino acids making up all proteins. The decoding of one molecule to another is performed by specific proteins and RNAs. Because the information stored in DNA is so central to cellular function, it makes intuitive sense that the cell would make mRNA copies of this information for protein synthesis...
20.9K
Proteins: From Genes to Degradation02:11

Proteins: From Genes to Degradation

11.9K
Within a biological system, the DNA encodes the RNA, and the nucleotide sequence in the RNA further defines the amino acid sequence in the protein. This is referred to as “The Central Dogma of Molecular Biology” - a term coined by Francis Crick.  Central dogma is a firm principle in biology that defines the flow of genetic information within any life form. The two fundamental steps in central dogma are - transcription and translation.
Transcription is the synthesis of RNA...
11.9K
Introduction to Biological Bases of Psychology01:30

Introduction to Biological Bases of Psychology

5.8K
Biopsychology serves as a vital bridge connecting the intricate domains of biology and psychology, shedding light on how biological systems influence psychological phenomena. This field scrutinizes the biological substrates of behavior and mental processes, emphasizing the nervous system along with the roles of neurotransmitters, hormones, and genetics. It also incorporates evolutionary perspectives to explain the adaptive nature of mental functions.
The nervous system, the cornerstone of...
5.8K
Upstream Processing01:27

Upstream Processing

102
Upstream processing represents a critical phase in biomanufacturing, wherein biological systems such as microorganisms, mammalian cells, or insect cells are cultivated to produce therapeutic proteins, vaccines, enzymes, or other biologically derived products. This phase encompasses all steps from the selection and genetic manipulation of the production organism to the cultivation of cells in bioreactors under tightly controlled environmental conditions.Host Selection and Genetic OptimizationThe...
102

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Techno-Economic Feasibility of Functional Snacks from Brewer's Spent Grain and Sweet Potato: A Simulation Study.

Foods (Basel, Switzerland)·2026
Same author

Untangling metabolic interactions of a nongrowing, hydrogen producing synthetic coculture through a multispecies metabolic flux analysis.

Bioresource technology·2025
Same author

Biosynthesis of Copper Nanoparticles with Medicinal Plants Extracts: From Extraction Methods to Applications.

Micromachines·2023
Same author

Current Trends of Bacterial and Fungal Optoproteins for Novel Optical Applications.

International journal of molecular sciences·2023
Same author

Biomolecule-Based Optical Metamaterials: Design and Applications.

Biosensors·2022
Same author

Assessment of the tolerance to Fe, Cu and Zn of a sulfidogenic sludge generated from hydrothermal vents sediments as a basis for its application on metals precipitation.

Molecular biology reports·2020

Related Experiment Video

Updated: May 5, 2026

The MultiBac Protein Complex Production Platform at the EMBL
13:51

The MultiBac Protein Complex Production Platform at the EMBL

Published on: July 11, 2013

16.1K

Comprehensive Teaching and Learning Approach for Bioprocess Integration: A Case Study in Chromoprotein Bioproduction.

Rigel Valentín Gómez-Acata1, Ana Laura Torres-Huerta1, Juan Silvestre Aranda-Barradas1

  • 1Tecnologico de Monterrey, School of Engineering and Sciences, Atizapán, Mexico.

Biochemistry and Molecular Biology Education : a Bimonthly Publication of the International Union of Biochemistry and Molecular Biology
|September 1, 2025
PubMed
Summary

This study introduces a holistic bioprocess design approach for undergraduate biotechnology education, integrating molecular biology, upstream/downstream processing, and economic evaluation for biomolecule production. Students gained comprehensive skills in lab-scale chromoprotein production and bioprocess evaluation.

Keywords:
Benchling application to an industrial strainSuperPro designerholistic bioprocess designindustrial biotechnologyproblem‐solving/decision making in bioprocess design

More Related Videos

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology
06:24

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology

Published on: December 15, 2017

10.2K
Use of High-Throughput Automated Microbioreactor System for Production of Model IgG1 in CHO Cells
08:15

Use of High-Throughput Automated Microbioreactor System for Production of Model IgG1 in CHO Cells

Published on: September 28, 2018

11.1K

Related Experiment Videos

Last Updated: May 5, 2026

The MultiBac Protein Complex Production Platform at the EMBL
13:51

The MultiBac Protein Complex Production Platform at the EMBL

Published on: July 11, 2013

16.1K
Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology
06:24

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology

Published on: December 15, 2017

10.2K
Use of High-Throughput Automated Microbioreactor System for Production of Model IgG1 in CHO Cells
08:15

Use of High-Throughput Automated Microbioreactor System for Production of Model IgG1 in CHO Cells

Published on: September 28, 2018

11.1K

Area of Science:

  • Biotechnology Engineering
  • Biochemical Engineering
  • Industrial Biotechnology

Background:

  • Bioprocess design education often lacks integrated approaches, focusing heavily on molecular aspects.
  • Key elements like lab-scale production, purification, and economic evaluation are frequently overlooked in academic programs.
  • There is a need for comprehensive training in holistic bioprocess development for industrial biomolecule production.

Purpose of the Study:

  • To propose and assess a comprehensive educational strategy for holistic bioprocess development in undergraduate biotechnology programs.
  • To integrate molecular biology, upstream/downstream processing, and economic evaluation into a cohesive learning experience.
  • To enhance student skills in designing and evaluating bioprocesses for industrial biomolecule production, using recombinant protein (chromoprotein) as a case study.

Main Methods:

  • Developed a curriculum integrating genetic engineering of Escherichia coli, upstream/bioreactor technology, and tailored downstream purification.
  • Implemented a collaborative project focused on recombinant chromoprotein production across multiple Biotechnology Engineering courses.
  • Utilized specialized software (Benchling, MATLAB, SuperPro Designer) for recombinant technology, process modeling, and economic analysis.

Main Results:

  • Students achieved a comprehensive understanding of lab-scale chromoprotein production.
  • Significant skill development was observed in genetic engineering, biomolecule production, bioreactor scaling, and upstream/downstream process selection.
  • Integration of software tools enhanced student confidence and proficiency in bioprocess evaluation and sizing, highlighting the importance of chromatography.

Conclusions:

  • The proposed holistic educational strategy effectively improved students' ability to design and evaluate bioprocesses.
  • This integrated approach better prepares future biotechnology engineers for industrial challenges in economic and sustainable biomolecule production.
  • The study underscores the value of hands-on projects and specialized software in biotechnology education.