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Updated: Sep 9, 2025

A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species
Published on: August 16, 2018
Regioselective Multicomponent Sulfonylation/Cyclization of Unactivated Alkenes to Access Sulfonylated Six- and
Ran Ding1,2, Tao Shu1, Pan-Ya Cui1
1College of Chemistry and Materials Engineering, Anhui Science and Technology University, Bengbu, Anhui 233000, P. R. China.
Abstract:
Radical cascade cyclization of alkenes involving the insertion of sulfur dioxide has proven to be a promising tool to access sulfonylnated heterocycle compounds, whereas cyclization of unactivated alkenes has been much less explored. Here, we developed a three-component cascade of unactive alkenes with sulfur dioxide and aryldiazonium tetrafluoroborates to generate sulfonylated tetrahydropyridines and azepines via the cleavage of alkenyl C-H bonds. Moreover, this protocol exhibited excellent chemical and regioselectivity and compatibility with broad functional groups.
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