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Updated: Sep 9, 2025

Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation
Published on: December 29, 2023
Enteroendocrine cells: the gatekeepers of microbiome-gut-brain communication
Esmée Grundeken1, Sahar El Aidy2,3
1Department of Microbiome Engineering, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands.
Abstract:
Enteroendocrine cells (EECs) are gut epithelial hormone-secreting cells, influenced by diet and the microbiome. EECs regulate local gastrointestinal functions and systemic signalling, including communication with the brain, while being linked to various diseases, yet their systemic integration remains underexplored. This review examines the metabolic and systemic roles of EECs, focusing on interactions with dietary components, the microbiome, and disease pathways, while identifying key research gaps to guide future studies.
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