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Related Concept Videos

Autophagy01:27

Autophagy

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Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
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Delivery Pathways to the Lysosome01:36

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Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
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Autophagic Cell Death01:18

Autophagic Cell Death

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Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
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Regulated Protein Degradation02:58

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It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
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Artificial Peptides as Autophagy Modulators.

Yuhai Cai1, Ling Qiu1, Boyu Zhang1

  • 1Center for Innovative Drug Discovery, Greater Bay Area Institute of Precision Medicine (Guangzhou), School of Pharmacy, Fudan University, Shanghai, P. R. China.

Chembiochem : a European Journal of Chemical Biology
|September 2, 2025
PubMed
Summary
This summary is machine-generated.

Artificial peptides offer a novel approach to modulate autophagy, a key cellular process. This review highlights advances in peptide-based tools for monitoring, inducing, and inhibiting autophagy for therapeutic potential.

Keywords:
autophagy regulatorcancerchemical modificationdrug developmentpeptide

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Area of Science:

  • Cell Biology
  • Biochemistry
  • Molecular Medicine

Background:

  • Autophagy is a fundamental cellular process crucial for maintaining homeostasis.
  • Dysregulation of autophagy is linked to significant diseases like cancer, neurodegeneration, and infections.
  • Targeting autophagy presents a promising therapeutic avenue.

Purpose of the Study:

  • To review recent advancements in artificial peptide-based autophagy modulators.
  • To explore peptide tools for monitoring, inducing, and inhibiting autophagy.
  • To discuss the potential of these peptides as therapeutic agents.

Main Methods:

  • Literature review of artificial peptide-based autophagy modulators.
  • Analysis of studies on peptide tools for autophagy monitoring.
  • Examination of research on peptide-based autophagy inducers and inhibitors.

Main Results:

  • Artificial peptides show promise as specific and biocompatible alternatives to small molecules.
  • Emerging peptide-based tools offer versatile strategies for autophagy modulation.
  • Recent progress includes novel monitoring, induction, and inhibition strategies.

Conclusions:

  • Artificial peptide-based modulators represent a significant advancement in autophagy research.
  • These peptides offer advantages in specificity and biocompatibility for therapeutic applications.
  • Further development holds potential for treating autophagy-related diseases.