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Related Experiment Video

Updated: Sep 9, 2025

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
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OCT-Defined Atrophic Age-Related Macular Degeneration Changes Associated with Deep Visual Sensitivity Losses: A

Zhichao Wu1,2, Barbara A Blodi3, Frank G Holz4

  • 1Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.

Ophthalmology Science
|September 2, 2025
PubMed
Summary

This study identified specific optical coherence tomography (OCT) features that define atrophic age-related macular degeneration (AMD) lesions associated with significant vision loss. These OCT criteria can help identify nonresponding areas in clinical trials for AMD treatments.

Keywords:
Age-related macular degenerationGeographic atrophyMicroperimetryOptical coherence tomographycRORA

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Quantitative Fundus Autofluorescence for the Evaluation of Retinal Diseases
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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Retinal Diseases

Background:

  • Age-related macular degeneration (AMD) is a leading cause of vision loss.
  • Atrophic AMD involves degeneration of the retinal pigment epithelium and photoreceptors.
  • Accurate identification of atrophic lesions is crucial for clinical trials.

Purpose of the Study:

  • To determine combinations of optical coherence tomography (OCT) findings that characterize atrophic AMD lesions.
  • To correlate these OCT features with repeatable deep visual sensitivity defects.

Main Methods:

  • 171 OCT scans from 60 eyes of 53 participants with incomplete retinal pigment epithelium and outer retinal atrophy (iRORA) were analyzed.
  • 12 readers annotated OCT B-scans for 7 features of RPE and outer retinal atrophy.
  • High-density targeted microperimetry was performed to assess visual sensitivity defects.

Main Results:

  • Complete RPE and outer retinal atrophy (cRORA) lesions (≥250 μm width) showed a 60% prevalence of significant vision defects.
  • Lesions with hypertransmission and complete RPE loss (≥500 μm) demonstrated 92-98% prevalence of defects.
  • Specific OCT criteria, including hypertransmission and RPE abnormalities, correlated strongly with nonresponding areas.

Conclusions:

  • Established OCT criteria can define atrophic AMD lesions with functional characteristics of nonresponding areas (≥90% prevalence of repeatable ≤10 dB defect).
  • These OCT-defined lesions can serve as clinically relevant endpoints for evaluating preventative treatments in end-stage atrophic AMD.