Related Experiment Video
Updated: Sep 9, 2025
05:49
Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
Published on: November 29, 2024
718
Infection-Triggered Antiphospholipid Syndrome: A Critical Overview.
Svitlana Smiyan1, Ganna Kuzmina2, Olena Garmish3
1Department of Internal Medicine II, Ivan Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.
Open Access Rheumatology : Research and Reviews
|September 2, 2025
Summary
Infection-induced antiphospholipid syndrome (APS) involves blood clots during infections. Understanding its unique causes and diagnostic challenges is crucial for better patient care.
Area of Science:
- Immunology
- Rheumatology
- Infectious Diseases
Background:
- Antiphospholipid syndrome (APS) is traditionally linked to autoimmune diseases.
- Infection-induced APS is an emerging subset characterized by thrombotic events during infections.
- This phenomenon is not well-defined, necessitating further research.
Purpose of the Study:
- To review current knowledge on infection-induced APS.
- To explore its pathogenesis, clinical features, and diagnostic difficulties.
- To highlight the need for standardized diagnostic criteria.
Main Methods:
- A narrative review of literature was performed.
- Searches were conducted in Medline and PubMed databases.
- 35 English-language articles published between 2014 and May 2025 were analyzed.
Main Results:
- Multiple mechanisms link infections to APS, including molecular mimicry and immune system activation.
- Clinical presentations vary, complicating differentiation from transient antiphospholipid antibody (aPL) positivity.
- Diagnostic challenges arise from fluctuating aPL levels and overlapping symptoms.
Conclusions:
- Infection-induced APS has a complex pathogenesis involving various immune pathways.
- Distinguishing infection-related aPL positivity from true APS is challenging.
- Standardized criteria are needed to address the temporal and immunological heterogeneity of infection-induced APS.
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