[Treatment of uremic hypogonadism with parlodel]

Signs of hypogonadism and an elevated prolactin level (EPL) were found in the blood serum of 12 men and 9 women with different stages of chronic renal insufficiency (CRI) as compared to 20 healthy persons. The treatment with parlodel, a EPL secretion inhibitor, at a dose of 2.5-7.5 mg a day for 1-6.5 mos raised potency in 10 men, brought the sperm composition to normal in 5. Dysfunctional uterine bleeding was cut short in 4 women, the menstrual cycle was resumed in 3, the absence of any effect was noted in 2. The EPL level decreased significantly in all the patients. The results of the parlodel therapy of uremic hypogonadism were discussed with respect to CRI gravity and duration and the time period of a therapeutic course. Problems concerning the pathogenesis of uremic hypogonadism were considered.