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Related Concept Videos

Introduction to Hemostasis01:05

Introduction to Hemostasis

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Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
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Formation of the Platelet Plug01:22

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The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
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Related Experiment Video

Updated: Sep 9, 2025

TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application
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Absorbable Adhesive Composite Hemostatic Sponge Based on Decellularized Extracellular Matrix and Mussel Adhesive

Hyegyo Cha1, Jaeyun Lee1, Dayoon Kang2

  • 1Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, 37673, Republic of Korea.

Advanced Healthcare Materials
|September 3, 2025
PubMed
Summary
This summary is machine-generated.

New bioinspired sponges combining decellularized extracellular matrix (dECM) and mussel adhesive protein (MAP) show superior hemostatic performance. These novel materials offer improved wound healing and reduced adverse effects compared to current clinical hemostats.

Keywords:
composite spongedecellularized extracellular matrixearly wound stabilizationinternal bleeding controlmussel adhesive protein

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Surgical Innovation

Background:

  • Current topical hemostats like Surgicel and Avitene can cause adverse effects such as hemolysis and inflammation, hindering wound healing.
  • There is a need for advanced hemostatic biomaterials with strong wet adhesion, appropriate degradation, and enhanced biocompatibility for internal applications.
  • Bioinspired materials, including decellularized extracellular matrix (dECM) and mussel adhesive protein (MAP), present promising alternatives due to their inherent biocompatibility and adhesive properties.

Purpose of the Study:

  • To develop and evaluate composite sponges integrating dECM and MAP for effective internal hemostasis and wound healing.
  • To investigate the synergistic effects of dECM and MAP in a composite material for enhanced hemostatic efficacy.
  • To compare the performance of the developed composite hemostat against clinically used agents in preclinical models.

Main Methods:

  • Fabrication of composite sponges with varying ratios of dECM and MAP.
  • In vitro assessment of hemostatic performance, hemocompatibility, and cytocompatibility.
  • In vivo evaluation in a warfarin-treated rat liver injury model to measure bleeding time and blood loss.
  • Histological analysis to assess wound healing outcomes, including necrosis, fibrosis, and debris.

Main Results:

  • The E50M50 formulation (9.1% dECM, 90.9% MAP) exhibited the most potent hemostatic capabilities, particularly enhancing secondary hemostasis.
  • E50M50 demonstrated excellent hemocompatibility and cytocompatibility, alongside a degradation profile suitable for early wound healing.
  • In vivo studies showed E50M50 significantly reduced bleeding time and blood loss compared to controls in a liver injury model.
  • Histological examination revealed superior early wound healing with E50M50, marked by reduced adverse tissue reactions compared to Avitene.

Conclusions:

  • Composite sponges of dECM and MAP represent a promising class of absorbable, adhesive hemostats for managing internal bleeding.
  • The synergistic combination of dECM and MAP offers enhanced hemostatic performance and biocompatibility.
  • These novel biomaterials have the potential to improve early-stage wound stabilization and healing outcomes, offering advantages over existing hemostatic agents.