Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

332
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
332
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

57
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
57
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

77
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
77
Nephrons01:10

Nephrons

3.4K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
3.4K
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

65
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
65
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

72
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
72

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From Ineligible to Transplanted: Heath and Cost benefits of Treatment Optimisation of HFrEF in Dialysis Patients.

European journal of cardiovascular nursing·2026
Same author

Domiciliary subcutaneous furosemide in patients with CKD and HF: a quality improvement project.

BMJ open quality·2025
Same author

Iron management and exercise training in individuals with chronic kidney disease: lived experiences.

Clinical kidney journal·2025
Same author

Current management of chronic kidney disease in type-2 diabetes-A tiered approach: An overview of the joint Association of British Clinical Diabetologists and UK Kidney Association (ABCD-UKKA) guidelines.

Diabetic medicine : a journal of the British Diabetic Association·2024
Same author

Acute kidney injury in acute heart failure-when to worry and when not to worry?

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2024
Same author

The dynamics and outcomes of AKI progression during the COVID-19 pandemic.

Nephrology (Carlton, Vic.)·2024

Related Experiment Video

Updated: Sep 9, 2025

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.6K

Cardiac Troponins in Kidney Disease.

Daniel Murphy1, Debasish Banerjee1

  • 1Renal and Transplantation Unit, St George's University Hospitals NHS Foundation Trust London, UK.

European Cardiology
|September 3, 2025
PubMed
Summary

Cardiac troponin levels differ in kidney disease patients, impacting diagnosis and prognosis. Understanding these changes is crucial for managing cardiovascular disease in this population.

Keywords:
Chronic kidney diseasedialysiskidney transplantationtroponin

More Related Videos

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
04:41

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Published on: July 3, 2018

8.2K
A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats
07:31

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats

Published on: December 2, 2016

10.1K

Related Experiment Videos

Last Updated: Sep 9, 2025

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.6K
Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
04:41

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Published on: July 3, 2018

8.2K
A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats
07:31

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats

Published on: December 2, 2016

10.1K

Area of Science:

  • Cardiology
  • Nephrology
  • Biomarker Research

Background:

  • Cardiovascular disease (CVD) is a leading cause of death in individuals with kidney disease.
  • Cardiac troponins are key biomarkers for diagnosing and predicting cardiac events like myocardial infarction (MI) and heart failure.
  • Kidney disease alters troponin levels due to reduced clearance and increased production, complicating interpretation.

Purpose of the Study:

  • To review the current evidence on cardiac troponin measurement and interpretation in patients with chronic kidney disease (CKD).
  • To examine troponin levels in patients undergoing dialysis or kidney transplantation.
  • To assess the relationship between troponin levels and cardiovascular outcomes in CKD populations.

Main Methods:

  • Literature review of studies on cardiac troponin in kidney disease patients.
  • Analysis of baseline troponin levels and changes over time.
  • Examination of troponin's role in predicting cardiovascular morbidity and mortality.
  • Evaluation of troponin use in acute cardiac settings for CKD patients.

Main Results:

  • Elevated baseline troponin levels are common in CKD, dialysis, and post-transplant patients.
  • Troponin levels in CKD patients may not correlate with acute MI as in the general population.
  • Interpreting troponin requires consideration of CKD-specific factors, including renal clearance and cardiorenal syndrome.

Conclusions:

  • Standard interpretation of cardiac troponins is challenging in kidney disease populations.
  • Further research is needed to establish optimal protocols for troponin use in CKD patients.
  • Accurate interpretation of cardiac troponins is vital for managing cardiovascular risk in individuals with kidney disease.