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Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...

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Updated: Sep 9, 2025

Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics

Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics

Published on: September 28, 2019

Understanding human embryogenesis by building programmable stem cell-based models.

Carly Guiltinan¹, Gerrald A Lodewijk¹, Sayaka Kozuki¹

¹Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, CA, USA; Genomics Institute, University of California Santa Cruz, Santa Cruz, CA, USA; Institute for the Biology of Stem Cells, University of California Santa Cruz, Santa Cruz, CA, USA.

Trends in Cell Biology

|September 3, 2025

Summary

This summary is machine-generated.

New stem cell-based embryo models mimic early development. Epigenome editing created programmed mouse embryos, offering potential for engineering human embryogenesis models.

Keywords:

CRISPR activation embryo models epigenome editing stem cells

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Last Updated: Sep 9, 2025

Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics

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Published on: September 28, 2019

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Published on: November 27, 2017

Area of Science:

Developmental Biology
Stem Cell Biology
Epigenetics

Background:

Studying early human development is challenging due to ethical and technical limitations.
Stem cell-based embryo models offer a promising alternative for investigating developmental processes.
Recent advances in epigenome editing have enabled the creation of programmed embryonic models.

Purpose of the Study:

To discuss the recent generation of programmed mouse embryo models using epigenome editing.
To explore the potential of these advancements for creating engineering models of human embryogenesis.

Main Methods:

Utilizing epigenome editing techniques to activate endogenous regulatory elements.
Generating programmed mouse embryo models.

Main Results:

Successful creation of programmed mouse embryo models through targeted activation of regulatory elements.
Demonstration of a novel approach to recapitulate aspects of early development.

Conclusions:

The development of programmed embryo models represents a significant achievement in developmental biology.
These models hold considerable potential for advancing our understanding of human embryogenesis and related disorders.
Future research can focus on translating these findings to engineer more sophisticated human embryonic models.