Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Microorganisms in Medicine and Therapeutics

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Inhalable Cryo-Shocked Tumor Cells for Synergistic Chemoimmunotherapy.

ACS applied materials & interfaces·2026

Same author

Permeable nanoreactor eye drop for enzymatic cascade-mediated treatment for acute retinal injury model mimicking geographic atrophy.

Nature communications·2026

Same author

Inhalable Respiratory Driven Penetration of Porous Microsphere-Based Mucosal Vaccine for Long-Term Immune Protection.

Advanced materials (Deerfield Beach, Fla.)·2026

Same author

Enhanced Uptake and Retention of an Acidic Sophorolipid Delivery System Boosts Acute Lung Injury Therapy.

ACS applied materials & interfaces·2026

Same author

Graphene-supported covalent organic framework nanosheets for high performance aqueous dual-ion batteries.

Chemical science·2025

Same author

In situ-formed immunotherapeutic hydrogel containing sphingosine-1-phosphate for enhanced lung cancer immunotherapy.

Science advances·2025

Search research articles

Related Experiment Video

Updated: Sep 9, 2025

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo

Published on: September 28, 2022

Inhalable Nanovaccine Based on Bioengineered Bacteria-Derived Membrane Vesicles Against Lung Metastasis.

Yu Miao¹, Hanlin Zhang¹, Cheng Wang¹

¹Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, 215123, China.

Advanced Materials (Deerfield Beach, Fla.)

|September 4, 2025

Summary

An inhalable nanovaccine, BMVax, effectively prevents lung metastasis by generating robust immune responses. This bacterial membrane-based vaccine (BMVax) offers a promising new strategy for combating metastatic lung cancer.

Keywords:

cancer immunotherapy genetically engineered bacteria inhalable nanovaccine lung metastasis membrane vesicles

More Related Videos

A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain

A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain

Published on: July 25, 2022

Studying the Role of Alveolar Macrophages in Breast Cancer Metastasis

Studying the Role of Alveolar Macrophages in Breast Cancer Metastasis

Published on: June 26, 2016

Related Experiment Videos

Last Updated: Sep 9, 2025

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo

Published on: September 28, 2022

A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain

A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain

Published on: July 25, 2022

Studying the Role of Alveolar Macrophages in Breast Cancer Metastasis

Studying the Role of Alveolar Macrophages in Breast Cancer Metastasis

Published on: June 26, 2016

Area of Science:

Immunology
Nanotechnology
Oncology

Background:

Lung metastases present a significant challenge in cancer therapy due to the lung's unique environment.
Conventional vaccines often fail to induce localized anti-tumor immunity in the lungs.

Purpose of the Study:

To develop and evaluate an inhalable nanovaccine, BMVax, for preventing and treating lung metastases.
To assess the immunogenicity and efficacy of BMVax compared to traditional subcutaneous vaccination.

Main Methods:

Engineered E. coli to produce bacterial membrane vesicles (BMVax) displaying specific antigens.
Administered BMVax via inhalation and assessed immune cell activation in lymph nodes and lung tissue.
Evaluated anti-metastatic efficacy in a B16-OVA lung metastasis model.

Main Results:

Inhaled BMVax significantly enhanced antigen cross-presentation and T-cell proliferation.
BMVax inhalation boosted key immune cell populations, including germinal center B cells, follicular helper T cells, and dendritic cells.
Achieved 83.3% complete prevention of lung metastasis, outperforming subcutaneous administration.

Conclusions:

BMVax is a potent inhalable cancer vaccine candidate for combating lung metastases.
Inhalation delivery route elicits superior localized anti-tumor immune responses compared to subcutaneous injection.
BMVax demonstrates significant therapeutic potential against metastatic lung malignancies.