Structurally Flexible (Thiazol-2-ylidene)Pd(Allyl)Cl Complexes for Suzuki-Miyaura Cross-Coupling of Aryl Halides and
Ruihong Wang1, Xiaoxia Han2, Jin Zhang2
1School of Food Science and Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.
Abstract:
This study introduces a new class of (NHC)Pd(allyl)Cl complexes featuring thiazol-2-ylidene ligands, which exhibit enhanced steric and electronic properties compared to those of traditional imidazol-2-ylidenes. These air-stable Pd(II)-NHC catalysts demonstrate superior reactivity in chemoselective Suzuki-Miyaura cross-couplings of aryl bromides and amides. Kinetic studies reveal their superior reactivity over traditional imidazol-2-ylidene-based complexes. The findings highlight the potential of thiazole-based carbenes in advancing Pd-catalyzed cross-coupling reactions.
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