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Transforming Cancer Diagnosis and Therapy Through Fluorescent Hydrogels: A Review
Elahe Masaeli1, Seshasai Srinivasan1,2, Amin Reza Rajabzadeh1,2
1School of Biomedical Engineering, McMaster University, 1280 Main Street West Hamilton, Hamilton, ON, L8S 4L8, Canada.
Advanced Healthcare Materials
|September 4, 2025
Summary
Engineered fluorescent hydrogels mimic the tumor microenvironment for advanced cancer diagnostics and therapeutics. These smart materials enable precise tracking, early treatment monitoring, and targeted drug delivery, revolutionizing oncology.
Area of Science:
- Biomaterials Science
- Cancer Research
- Nanotechnology
Background:
- Recent advancements in cancer care include novel drug delivery, functional imaging, and biosensors.
- Engineered hydrogels that mimic the tumor microenvironment are emerging as key tools in oncology.
Purpose of the Study:
- To review methods for fluorescent labeling of hydrogels.
- To explore applications of fluorescent hydrogels in cancer treatment, biorecognition, and visualization.
- To discuss challenges and future directions for fluorescent hydrogels in cancer management.
Main Methods:
- Integration of fluorescent agents into hydrogel structures for enhanced imaging and tracking.
- Encapsulation of therapeutic agents (e.g., chemotherapeutics, antibodies) within fluorescent hydrogels.
- Development of fluorescent hydrogel-based biosensors for monitoring tumor characteristics and treatment response.
Main Results:
- Fluorescent hydrogels enable real-time tracking, precise imaging, and monitoring of tumor progression.
- These systems facilitate early detection of treatment effects and assessment of therapeutic targeting.
- Fluorescent hydrogels allow for localized, controlled release of various cancer therapeutics.
Conclusions:
- Fluorescent hydrogels offer significant potential in preclinical, diagnostic, and therapeutic cancer applications.
- Continued development is crucial for overcoming current challenges and realizing the full potential of these materials.
- These advanced materials are poised to revolutionize cancer diagnostics and treatment strategies.
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