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Updated: Sep 9, 2025

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Copper-Catalyzed Selective 1,2-Reduction of Quinolines
Narasingan Hariharan1, Chidambaram Gunanathan1
1School of Chemical Sciences, National Institute of Science Education and Research, An OCC of Homi Bhabha National Institute, Bhubaneswar 752050, India.
Abstract:
Selective reduction of heteroaromatic compounds to partially hydrogenated, dearomatized molecules is a tantalizing task. A well-defined, air stable, and pyridine-based Cu(II) NNN pincer complex is developed, which catalyzes selective 1,2-reduction of quinolines. The unstable 1,2-hydrogenated quinolines are transformed into the corresponding amides and isolated in good yields. Mechanistic studies confirmed that the reaction proceeds via molecular species and the formation of an unexpected copper bimetallic intermediate, which facilitates the catalysis through metal-ligand cooperation.
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