Dementia with Lewy Bodies and Sleep Dysfunction

Neurodegeneration in dementia with Lewy bodies affects all crucial networks responsible for sleep control and as a result, the sleep cycle is heavily disturbed. Certain sleep syndromes such as rapid eye movement sleep behavior disorder and hypersomnia are particularly common and characteristic features of the disease, but patients also suffer from insomnia, sleep disordered breathing, movement disorders during sleep, or nighttime urinary dysfunction. Several treatment options are available nowadays; however, more trials on efficacy and safety in this population are still needed.