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Related Concept Videos

Bioequivalence: Overview01:16

Bioequivalence: Overview

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Pharmaceutical equivalents, by definition, are drug products with the same active ingredient in the same quantities, encapsulated in identical dosage forms, and intended for the same administration routes. These pharmaceutical equivalents are deemed bioequivalent if the bioavailability of the active entity in the drug preparations is similar. Moreover, pharmaceutical equivalents demonstrating bioequivalence are also regarded as therapeutically equivalent. This means that when used as directed,...
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Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
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Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence01:22

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

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Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
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Bioequivalence of Drugs: Drugs with Multiple Indications01:09

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The concept of therapeutic equivalence (TE) in drugs with multiple indications is complex. A generic drug may be therapeutically equivalent to a brand-name product for one specific indication, but this doesn't necessarily mean it's equivalent for all other indications. Evidence of TE in one patient group and bioequivalence shown in healthy volunteers can support—but not confirm—TE for other indications. However, definitive proof requires individual clinical studies for each...
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Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...
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Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
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Related Experiment Video

Updated: May 6, 2026

Effects of Allogeneic Platelet-Rich Plasma PRP on the Healing Process of Sectioned Achilles Tendons of Rats: A Methodological Description
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Effects of Allogeneic Platelet-Rich Plasma PRP on the Healing Process of Sectioned Achilles Tendons of Rats: A Methodological Description

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Comparison of PRP Injections Versus Corticosteroid Injections in Plantar Fasciitis: Systematic Review and

Rafael Rayo-Martín1, Rafael Rayo-Rosado2, Ana María Rayo-Pérez2

  • 1Departamento de Podología, University of Seville, Sevilla, Spain.

Foot & Ankle Specialist
|September 6, 2025
PubMed
Summary

Platelet-rich plasma (PRP) offers a safe and effective treatment for plantar fasciitis pain, outperforming corticosteroids in medium-term pain reduction. This makes PRP a recommended option for managing chronic plantar fasciitis.

Keywords:
corticosteroidsplantar fascitisplatelet-rich plasma

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Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis
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Predictive Measurement for Windlass Change in Length and Selected Treatment Outcomes in Chronic Plantar Fasciitis
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Effects of Allogeneic Platelet-Rich Plasma PRP on the Healing Process of Sectioned Achilles Tendons of Rats: A Methodological Description
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Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis
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Predictive Measurement for Windlass Change in Length and Selected Treatment Outcomes in Chronic Plantar Fasciitis
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Predictive Measurement for Windlass Change in Length and Selected Treatment Outcomes in Chronic Plantar Fasciitis

Published on: March 1, 2024

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Area of Science:

  • Orthopedics
  • Regenerative Medicine
  • Sports Medicine

Background:

  • Plantar fasciitis (PF) is a prevalent cause of foot pain, impacting 10% of adults.
  • Chronic PF cases often necessitate advanced treatments beyond conservative measures.
  • Current treatments vary, with corticosteroids offering short-term relief but carrying risks, while platelet-rich plasma (PRP) shows promise for long-term benefits.

Purpose of the Study:

  • To compare the efficacy of platelet-rich plasma (PRP) versus corticosteroid injections for treating plantar fasciitis (PF).
  • To evaluate pain reduction using visual analog scale (VAS) scores in patients with PF receiving PRP or corticosteroid treatment.

Main Methods:

  • A systematic review and meta-analysis of randomized clinical trials (RCTs) adhering to PRISMA guidelines.
  • Searched major databases (PubMed, Scopus, Cochrane, Web of Science) for studies comparing PRP and corticosteroids in PF patients from 2019 to April 2024.
  • Analyzed VAS pain scores using mean differences and confidence intervals, assessing heterogeneity and employing random- or fixed-effects models as appropriate.

Main Results:

  • Thirteen RCTs involving 901 patients (497 PRP, 404 corticosteroids) were included.
  • No significant short-term difference in pain reduction was observed between PRP and corticosteroid groups (P = .85).
  • Platelet-rich plasma demonstrated significantly superior outcomes in VAS pain scores in the medium term compared to corticosteroids (P < .00001).

Conclusions:

  • Platelet-rich plasma (PRP) is a safe and effective therapeutic option for plantar fasciitis pain.
  • PRP offers superior medium-term pain relief and functional improvement compared to corticosteroid injections for chronic plantar fasciitis.
  • PRP is recommended as a preferred treatment modality for managing chronic plantar fasciitis.