Related Experiment Video
Updated: Jan 18, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
10-(4-Fluoro-phen-yl)-4-[(4-fluoro-phen-yl)amino]-5-phenyl-5,8,9,10-tetra-hydro-pyrimido[4,5-b]quin-olin-6(7H)-one
Sizwe J Zamisa1, Adesola A Adeleke1, Bernard Omondi1
1School of Agriculture and Science, Discipline of Chemistry, University of KwaZulu-Natal, Private Bag X54001, Durban, 4000, Republic of , South Africa.
None:
The asymmetric unit of the title compound, C29H22F2N4O, consists of one mol-ecule in which the pyrimidinyl and anilinyl units exhibit near coplanarity, subtending a dihedral angle of 10.22 (7)°. In contrast, the di-hydro-pyridine and phenyl rings are nearly perpendicular, making angles of 88.66 (7) and 89.14 (7)°. The crystal packing features alternating C-H⋯π and C-F⋯π inter-actions that generate a corrugated two-dimensional supra-molecular network in the crystallographic ac plane. This structure is further consolidated into a three-dimensional architecture by C-H⋯F hydrogen bonding.
More Related Videos
Related Concept Videos
Five-Membered Heterocyclic Aromatic Compounds: Overview
Aryldiazonium Salts to Azo Dyes: Diazo Coupling

![Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60786.jpg&w=3840&q=50)