Biosynthesized Silver Nanoparticles Modulate Inflammation in a Palatine Wound Model.

Area of Science:

• Biomaterials Science
• Nanotechnology
• Oral Biology

Background:

• Oral and palatal mucosal wounds present challenges in healing.
• Developing effective therapeutic strategies is crucial for improving patient outcomes.
• Nanoparticles offer novel properties for tissue regeneration.

Purpose of the Study:

• To compare silver nanoparticles (AgNPs) synthesized with Curcumin or Açai against commercial treatments and photobiomodulation for rat palatal wound healing.
• To evaluate the efficacy of these novel AgNP formulations in accelerating tissue repair and resolving inflammation.

Main Methods:

• In vitro cell viability assays were performed to assess nanoparticle toxicity.
• Rat palatal wounds were created and treated daily for 5 days with different therapeutic agents.
• Histological and biochemical analyses were conducted on collected palatal mucosa tissue.

Main Results:

• AgNPs synthesized with Curcumin (AgNPs-Cur) significantly reduced pro-inflammatory cytokines and oxidant markers.
• AgNPs-Cur increased anti-inflammatory cytokines, wound contraction rate, and collagen area.
• AgNPs-Cur treatment led to a reduced inflammatory infiltrate compared to control groups.

Conclusions:

• The tested therapies, particularly AgNPs-Cur, effectively resolved inflammation and accelerated palatal tissue repair.
• This study suggests AgNPs synthesized with natural compounds are cost-effective and efficient alternatives for oral mucosa wound healing.
• These findings indicate potential improvements over standard commercial treatments for palatal wound management.