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Invasive Gastrointestinal Mucormycosis Presenting as Neutropenic Enterocolitis: A Case Report.
Hamad J AlBassam1, Wael Alanazi2, Faisal Al Rashid3
1Department of Medicine, Infectious Disease Section, King Fahad Specialist Hospital, Dammam, Saudi Arabia.
The American Journal of Case Reports
|September 8, 2025
Summary
Gastrointestinal mucormycosis is a dangerous fungal infection often missed. Early recognition and aggressive treatment, including surgery and antifungals, are crucial for survival in high-risk patients.
Area of Science:
- Mycology
- Gastroenterology
- Oncology
Background:
- Gastrointestinal mucormycosis is a rare but deadly fungal infection.
- Diagnosis is challenging due to non-specific symptoms.
- Neutropenic patients undergoing chemotherapy are at high risk.
Purpose of the Study:
- To present a case of gastrointestinal mucormycosis.
- To highlight diagnostic and management challenges.
- To emphasize the importance of early intervention.
Main Methods:
- Case report of a 19-year-old male with B-cell acute lymphoblastic leukemia.
- Diagnosis via contrast-enhanced CT and histopathology.
- Treatment involved surgery, intravenous amphotericin B, and azole antifungals.
Main Results:
- The patient developed neutropenic colitis and ileocecal perforation.
- Initial treatment led to improvement, but relapse occurred due to non-compliance.
- Repeat surgery and combination antifungal therapy resulted in sustained remission.
Conclusions:
- Early recognition and high suspicion are vital for at-risk patients.
- Aggressive medical and surgical management are essential for survival.
- Multifaceted treatment strategies improve outcomes in gastrointestinal mucormycosis.
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