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Published on: November 21, 2013
Antipsychotic medication non-adherence and its associated factors among patients with schizophrenia in Ethiopia: A
Yuxin Huang1, Tafesse Adigawe2, Siyuan Tang3
1Teaching and Research Section of Clinical Nursing, Xiangya Hospital of Central South University, Changsha, Hunan Province, China; Xiangya School of Nursing, Central South University, Changsha, Hunan Province, China.
Objectives:
This study aimed to assess antipsychotic medication non-adherence among patients with schizophrenia in Ethiopia, and to explore its associated factors based on the Multidimensional Adherence Model.
Methods:
This study is a cross-sectional study using convenience sampling enrolled 406 schizophrenia patients from July 17 to August 25, 2023. Data collection included medication non-adherence, sociodemographic factors, patient-related factors, therapy-related factors, condition-related factors, and healthcare system-related factors. Medication non-adherence was measured via the Morisky Medication Adherence Scale. Social support was assessed using the Oslo-3 social support scale (OSSS-3), and medication attitudes were measured via the drug attitude inventory-10 (DAI-10). Logistic regression analyzed associations between these factors and medication non-adherence.
Results:
The antipsychotic medication non-adherence rate among Ethiopian schizophrenia patients was 42.4 %, with significant associated factors including no formal education (AOR = 3.093, 95 %CI: 1.426-6.709, P = 0.004), impaired insight (poor insight: AOR = 3.151, 95 %CI: 1.765-5.624, P < 0.001; partial insight: AOR = 4.309, 95 %CI: 2.463-7.539, P < 0.001), perceived stigma because of schizophrenia (AOR = 1.904, 95 %CI: 1.201-3.016, P = 0.006), polypharmacy (AOR = 2.133, 95 %CI: 1.339-3.396, P = 0.001), disease duration <5 years (AOR = 2.313, 95 %CI: 1.361-3.932, P = 0.002), and current substance use (AOR = 2.007, 95 %CI: 1.266-3.181, P = 0.003).
Conclusion:
In this research, the antipsychotic medication non-adherence was relatively high, and seven significant associated factors were identified. Future research should target these factors to develop more effective strategies to improve antipsychotic medication adherence among patients with schizophrenia in Ethiopia.
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