Participant-Reported Outcome Measures After Transrectal and Transperineal Prostate Biopsy in a Randomized Clinical...

Area of Science:

• Urology
• Surgical Outcomes
• Patient-Reported Outcomes

Background:

• Patient-reported outcome measures (PROMs) are vital for medical intervention recommendations.
• Prospective comparative studies on PROMs following transrectal biopsy (TR-Bx) versus transperineal biopsy (TP-Bx) are limited.

Purpose of the Study:

• To conduct a comparative analysis of PROMs between TR-Bx and TP-Bx.
• To evaluate pain and functional outcomes reported by patients undergoing prostate biopsy.

Main Methods:

• A randomized trial (ProBE-PC) comparing TR-Bx and TP-Bx under local anesthesia (LA).
• Collection of participant-reported pain scores (Numerical Rating Scale) and functional outcomes (IPSS, IPSS-QoL, IIEF-5).
• Analysis of clinically significant pain (score ≥ 4) and minimum clinically important changes in functional scores.

Main Results:

• TP-Bx was associated with significantly higher pain scores at multiple time points compared to TR-Bx.
• Clinically significant pain was more frequent with TP-Bx during LA injection and on the evening of the procedure.
• Increased urinary dysfunction (IPSS and IPSS-QoL worsening) was reported more frequently after TP-Bx than TR-Bx.

Conclusions:

• TP-Bx leads to higher rates and levels of pain compared to TR-Bx.
• Patients undergoing TP-Bx experience increased urinary dysfunction post-procedure.
• These findings are clinically relevant for patient counseling regarding prostate biopsy choices.