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Updated: Jan 18, 2026

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Coherence between Brain Cortical Function and Neurocognitive Performance during Changed Gravity Conditions
Published on: May 23, 2011
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Otolaryngological and Neuro-Vestibular Considerations for Commercial Spaceflight
Aerospace Medicine and Human Performance
|September 9, 2025
Summary
Commercial spaceflight (CSF) is growing, but medical data for non-astronauts is limited. This review found motion sickness and disorientation are common topics, with gaps in other ear, nose, and throat (ENT) conditions for space travelers.
Area of Science:
- Aerospace Medicine
- Otolaryngology
- Neuro-Vestibular Science
Background:
- The commercial spaceflight (CSF) market is expanding, increasing access for individuals without professional astronaut qualifications.
- Nonprofessional space travelers may have pre-existing medical conditions, complicating spaceflight preparation and risk assessment.
- Ear, nose, and throat (ENT) and neuro-vestibular considerations are crucial for this growing demographic.
Purpose of the Study:
- To conduct a scoping review of biomedical literature concerning ENT and neuro-vestibular conditions relevant to nonprofessional space travelers.
- To identify knowledge gaps in the medical preparation and risk assessment for commercial spaceflight passengers.
Main Methods:
- A scoping review methodology was employed, adhering to Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines.
- An initial search yielded 3232 articles, which were systematically filtered by two reviewers to 142 relevant publications based on strict inclusion/exclusion criteria.
Main Results:
- Motion sickness and spatial disorientation were the most frequently addressed topics in the reviewed literature.
- Limited information was found regarding other critical ENT issues, including hearing loss, sino-nasal dysfunction, and pharyngeal conditions.
Conclusions:
- Optimal medical guidance for CSF passengers requires integrating current biomedical research with aeromedical expertise.
- Establishing an industry-wide CSF medical database is recommended to address identified care gaps and enhance specialized aerospace medical knowledge.
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