Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

792
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
792
Stimulants01:29

Stimulants

848
Stimulants are substances that enhance neural activity and elevate dopamine levels in the brain, leading to their highly addictive nature. These drugs include cocaine, amphetamines, MDMA, caffeine, and nicotine, each with distinct mechanisms of action and varied health implications.
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
848
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

403
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
403
Assumptions of Survival Analysis01:15

Assumptions of Survival Analysis

401
Survival models analyze the time until one or more events occur, such as death in biological organisms or failure in mechanical systems. These models are widely used across fields like medicine, biology, engineering, and public health to study time-to-event phenomena. To ensure accurate results, survival analysis relies on key assumptions and careful study design.
401
Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

202
Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
202
Stress and Mental Health01:30

Stress and Mental Health

816
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
816

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Polysubstance use: delay discounting in relationship to remission.

Scientific reports·2026
Same author

Multilevel Stewardship Intervention for Use of Anticoagulation-Antiplatelet Therapy.

JAMA internal medicine·2026
Same author

Mobile intervention for emerging adults with regular cannabis use: a micro-randomized trial.

Lancet regional health. Americas·2026
Same author

Motivating Patients to Engage in Evidence-Based Strategies to Prevent Diabetes: A Randomized Controlled Trial.

American journal of preventive medicine·2026
Same author

Exploring risk tolerance among individuals who use opioids.

Experimental and clinical psychopharmacology·2026
Same author

Integrated behavioral care in general hepatology increases alcohol use disorder treatment in veterans.

Hepatology communications·2026

Related Experiment Video

Updated: Jan 18, 2026

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

15.1K

Contingency Management for Stimulant Use Disorder and Association With Mortality: A Cohort Study.

Lara N Coughlin1, Devin C Tomlinson1, Lan Zhang1

  • 1Michigan Innovations in Addiction Care Through Research and Education (MI-ACRE) Program, Department of Psychiatry, University of Michigan, Ann Arbor.

The American Journal of Psychiatry
|September 10, 2025
PubMed
Summary
This summary is machine-generated.

Contingency management (CM) significantly reduces mortality risk for stimulant use disorder (StUD) patients. This behavioral intervention, offering tangible rewards for abstinence, shows a 41% decrease in death rates in a large healthcare system.

Keywords:
Behavioral TreatmentCocaineContingency ManagementMethamphetamineStimulantsSubstance-Related and Addictive Disorders

More Related Videos

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
09:16

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

15.7K
Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD
10:02

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD

Published on: March 12, 2020

16.6K

Related Experiment Videos

Last Updated: Jan 18, 2026

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

15.1K
A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
09:16

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

15.7K
Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD
10:02

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD

Published on: March 12, 2020

16.6K

Area of Science:

  • Addiction Medicine
  • Public Health
  • Behavioral Science

Background:

  • Stimulant overdose deaths are rising, with no FDA-approved medications for stimulant use disorder (StUD).
  • Contingency management (CM) is an effective behavioral intervention for near-term StUD treatment, but its long-term impact on mortality is unknown.

Purpose of the Study:

  • To investigate if patients with StUD receiving CM experience a reduced risk of mortality.
  • To evaluate the long-term effectiveness of CM in a real-world clinical setting.

Main Methods:

  • Retrospective cohort study utilizing linked electronic health records and death records from the Veterans Health Administration (VHA).
  • Included 1,481 patients with StUD who received CM and 1,481 matched controls from July 2018 to December 2020.
  • Primary outcome: all-cause mortality within one year post-index CM visit, analyzed using Cox proportional hazards models.

Main Results:

  • Patients with StUD who received CM were 41% less likely to die within one year compared to controls (aHR=0.59, 95% CI=0.36, 0.95).
  • This represents the first evidence linking CM use to reduced mortality in StUD patients.

Conclusions:

  • Contingency management (CM) is associated with a significant reduction in mortality risk for patients with stimulant use disorder (StUD).
  • Findings support the implementation of CM in real-world healthcare settings to improve long-term outcomes for StUD.
  • This study highlights the critical role of behavioral interventions in addressing the rising tide of stimulant-related mortality.