Related Experiment Video
Updated: Jan 18, 2026

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
Published on: April 9, 2018
Catalyst-Free Decarboxylative Couplings of Zinc Polyfluorobenzoates with Thiosulfonates for Accessing Polyfluoroaryl
Wen-Wen Wang1, Xin-Ying Li1, Yuan-Yuan Wang1
1Technical Institute of Fluorochemistry (TIF), School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China.
Abstract:
An efficient and environmentally friendly decarboxylative thiolation of zinc polyfluorobenzoates with odorless, nontoxic, and bench-stable thiosulfonates under catalyst-, ligand-, and additive-free conditions was realized. The uncatalyzed thioetherifications proceeded effectively via CO2 extrusion in DMA, leading to a wide variety of polyfluoroaryl sulfides in moderate to good yields with broad functional group compatibility. In addition, scale-up synthesis and late-stage modification of bioactive complex molecules could be achieved, as well. Notably, a step-economical one-pot protocol with the straightforward utilization of polyfluorobenzoic acids and Zn(OH)2 as precursors for in situ formation of zinc polyfluorobenzoates could also be successfully accomplished. Moreover, control experiments indicated that zinc polyfluorobenzoate was a more effective polyfluoroarylating agent in the current decarboxylative thioetherification when compared to its magnesium, potassium, and sodium counterparts.
More Related Videos
09:16Synthesis of Terpolymers at Mild Temperatures Using Dynamic Sulfur Bonds in PolyS-Divinylbenzene
Published on: May 20, 2019
04:51Author Spotlight: Functionalizing Metal-Organic Frameworks: Advancements, Challenges, and the Power of Post-Synthetic Ligand Exchange
Published on: June 23, 2023
Related Concept Videos
Preparation and Reactions of Sulfides
Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene
Preparation and Reactions of Thiols
Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions
Electrophilic Aromatic Substitution: Sulfonation of Benzene
Nucleophilic Aromatic Substitution of Aryldiazonium Salts: Aromatic SN1
In the Sandmeyer reaction, for example, the diazonio group is replaced by a chloro, bromo,...