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Prognostic Implications of Cutaneous Metastases in Colorectal Cancer: A Comprehensive Systematic Review and
Elliot Tokarski1, Pierre-Louis Conan2, Hugo Picchi3
1Department of Digestive Surgery, Begin Military Teaching Hospital, Saint Mandé, France.
Cutaneous metastases in colorectal cancer indicate poor prognosis and short survival. However, treating skin metastases significantly improves overall survival, regardless of the treatment method used.
Area of Science:
- Oncology
- Dermatology
- Cancer Research
Background:
- Cutaneous metastases in colorectal cancer significantly impact patient survival.
- Effective management strategies are crucial for improving outcomes.
Purpose of the Study:
- To assess the global prognosis of skin metastases in colorectal cancer patients.
- To analyze the impact of treatment on survival rates.
Main Methods:
- Systematic review of PubMed database (1990-2023) for English articles.
- Inclusion of studies on clinical outcomes and systematic reviews of colorectal cancer with skin metastases.
- Independent data extraction on histology, locations, and prognosis.
Main Results:
- Rectal adenocarcinoma was the most common primary site (58%).
- Metachronous metastases were prevalent (61%).
- Treatment of cutaneous metastases significantly improved overall survival (p < 0.001).
Conclusions:
- Cutaneous metastases are associated with a poor prognosis and limited survival.
- Skin metastases may serve as a marker for aggressive metastatic disease.
- Treatment of cutaneous metastases offers a survival benefit.
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