Related Experiment Video
Updated: Jan 18, 2026
06:42
Author Spotlight: Exploring the Antibacterial Effects of Zinc Oxide Nanoparticles in Overcoming Antibiotic Resistance
Published on: September 27, 2024
2.7K
The secret weapon to reduce multidrug-resistant Gram-negative infections: can vaccines help decrease MDR risk?
Maddalena Peghin1, Paolo Antonio Grossi
1Infectious and Tropical Diseases Unit, Department of Medicine and Surgery, University of Insubria-ASST-Sette Laghi, Varese, Italy.
Current Opinion in Infectious Diseases
|September 12, 2025
Summary
Vaccination is a key strategy against antimicrobial resistance (AMR), particularly multidrug-resistant (MDR) Gram-negative bacteria (GNB). Vaccines reduce infections and antibiotic use, offering a low-risk alternative to combat AMR.
Area of Science:
- Microbiology
- Immunology
- Public Health
Background:
- Antimicrobial resistance (AMR) poses a significant global health threat.
- Developing new antibiotics is complex and time-consuming.
- Preventive strategies like vaccination are crucial to combat AMR.
Purpose of the Study:
- To review the role of vaccines in fighting AMR.
- To focus on multidrug-resistant (MDR) Gram-negative bacteria (GNB).
- To explore current and potential vaccine applications against AMR.
Main Methods:
- Literature review of existing studies on vaccines and AMR.
- Analysis of vaccine impact on MDR GNB infections.
- Evaluation of vaccine development pipeline for GNB.
Main Results:
- Vaccination is an underestimated tool against AMR in all countries.
- Vaccines reduce MDR bacterial infections and antibiotic consumption.
- The risk of vaccine-induced resistance is very low compared to antibiotics.
Conclusions:
- Expanding vaccine use and developing new vaccines are vital AMR control strategies.
- Further research is needed to optimize vaccine use against AMR.
- Vaccines offer a safe and effective complementary approach to antibiotics for AMR control.
Related Concept Videos
01:27Combined Effects of Drugs: Synergism
6.8K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
6.8K
01:30Development of Antibiotic Resistance
1.3K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.3K
01:29Microorganisms in Medicine and Therapeutics
989
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
989
01:22Healthcare Associated Infections II: Preventive Measures
3.6K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
3.6K
01:28Antimicrobial Effectiveness
913
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
913
01:23Antimicrobial Proteins
13.0K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
13.0K