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The secret weapon to reduce multidrug-resistant Gram-negative infections: can vaccines help decrease MDR risk?

Maddalena Peghin1, Paolo Antonio Grossi

  • 1Infectious and Tropical Diseases Unit, Department of Medicine and Surgery, University of Insubria-ASST-Sette Laghi, Varese, Italy.

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|September 12, 2025
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Summary
This summary is machine-generated.

Vaccination is a key strategy against antimicrobial resistance (AMR), particularly multidrug-resistant (MDR) Gram-negative bacteria (GNB). Vaccines reduce infections and antibiotic use, offering a low-risk alternative to combat AMR.

Keywords:
Gram-negative bacteriaantimicrobial resistancemultidrug resistantpreventionvaccination

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Area of Science:

  • Microbiology
  • Immunology
  • Public Health

Background:

  • Antimicrobial resistance (AMR) poses a significant global health threat.
  • Developing new antibiotics is complex and time-consuming.
  • Preventive strategies like vaccination are crucial to combat AMR.

Purpose of the Study:

  • To review the role of vaccines in fighting AMR.
  • To focus on multidrug-resistant (MDR) Gram-negative bacteria (GNB).
  • To explore current and potential vaccine applications against AMR.

Main Methods:

  • Literature review of existing studies on vaccines and AMR.
  • Analysis of vaccine impact on MDR GNB infections.
  • Evaluation of vaccine development pipeline for GNB.

Main Results:

  • Vaccination is an underestimated tool against AMR in all countries.
  • Vaccines reduce MDR bacterial infections and antibiotic consumption.
  • The risk of vaccine-induced resistance is very low compared to antibiotics.

Conclusions:

  • Expanding vaccine use and developing new vaccines are vital AMR control strategies.
  • Further research is needed to optimize vaccine use against AMR.
  • Vaccines offer a safe and effective complementary approach to antibiotics for AMR control.