Coaxial Electrospray of Nanodrug-Loaded Porous Polylactic Acid/Poly(Ethylene Oxide) Core-Shell Microparticles for...

Area of Science:

• Biomaterials Engineering
• Nanotechnology
• Pulmonary Medicine

Background:

• Biocompatible microparticles are crucial for targeted and sustained drug delivery, especially for lung diseases like chronic obstructive pulmonary disease (COPD).
• Electrospray technology offers a method for fabricating microparticles with controlled size and morphology for enhanced pulmonary drug delivery.

Purpose of the Study:

• To fabricate porous core-shell microparticles encapsulating bioactive telodendrimer (TD) nanodrug carriers using electrospray.
• To optimize microparticle characteristics (size, morphology, porosity) for deep lung deposition and controlled drug release in COPD treatment.
• To evaluate the biocompatibility and therapeutic potential of the fabricated microparticles.

Main Methods:

• Utilized electrospray technology for the fabrication of porous core-shell microparticles.
• Systematically investigated the effects of solution viscosity and surface tension on microparticle formation.
• Conducted in vitro cytotoxicity, hemolysis, and drug release studies to assess biocompatibility and therapeutic efficacy.

Main Results:

• Achieved spherical microparticles with uniform porosity (1-5 μm) suitable for sustained drug release through optimized electrospray parameters and polymer concentration.
• Demonstrated that surfactant addition reduced particle size and enhanced pore formation, albeit with some morphological variability.
• Confirmed the biocompatibility and therapeutic potential of the microparticles through in vitro assessments.

Conclusions:

• Electrospray-derived core-shell microparticles show significant promise for non-invasive treatment of COPD.
• Further research into polymer-solvent interactions and formulation refinement is warranted for optimizing pulmonary drug delivery.