Related Experiment Video
Updated: Jan 18, 2026

05:58
Testing Acetylcholine Followed by Adenosine for Invasive Diagnosis of Coronary Vasomotor Disorders
Published on: February 3, 2021
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5-Fluorouracil-Induced Microvascular Vasospasm Diagnosed by Coronary Functional Testing.
Rimsha Rana1, Ryan L Wallace2, Ron Waksman2
1Department of Medicine, MedStar Georgetown University Hospital, Washington, DC, USA.
JACC. Case Reports
|September 12, 2025
Summary
Coronary vasospasm caused by 5-fluorouracil (5-FU) chemotherapy can be diagnosed using coronary functional testing with acetylcholine provocation. This method helps identify patients who benefit from calcium-channel blockers and adjusted 5-FU administration.
Area of Science:
- Cardiology
- Oncology
- Pharmacology
Background:
- 5-fluorouracil (5-FU), a component of FOLFOX chemotherapy, is associated with coronary vasospasm.
- Diagnosing 5-FU-induced coronary vasospasm can be challenging, potentially leading to chemotherapy cessation.
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