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Association Between Cardiovascular Disease and Complete Edentulism in U.S. Adults
Saud Alyahya1, Basel Hamoud1, Ali Alqattan1
1Kuwait Ministry of Health, Kuwait City 15462, Kuwait.
Journal of Clinical Medicine
|September 13, 2025
Summary
Complete tooth loss, or edentulism, is linked to a higher prevalence of cardiovascular disease (CVD) in U.S. adults. This study highlights a significant association between edentulism and conditions like heart attack and stroke.
Area of Science:
- Public Health
- Epidemiology
- Dental Health
Background:
- Cardiovascular disease (CVD) and complete tooth loss (edentulism) are significant public health issues.
- Both conditions share common risk factors and inflammatory pathways.
- This research explores the connection between complete edentulism and CVD prevalence.
Purpose of the Study:
- To investigate the association between complete tooth loss and cardiovascular disease in a representative U.S. adult population.
- To analyze the relationship using data from the National Health and Nutrition Examination Survey (NHANES).
Main Methods:
- Utilized Poisson regression analysis on the 2015-2018 NHANES dataset.
- Included 11,287 participants, with 15.62% being completely edentulous.
- Adjusted for demographic factors (age, sex, education, income, race/ethnicity) and health indicators (diabetes, BMI).
Main Results:
- Individuals with myocardial infarction, coronary heart disease, congestive heart failure, and stroke showed a significantly higher prevalence of complete edentulism.
- Adjusted prevalence ratios (PR) for CVD conditions ranged from 1.44 to 1.58 compared to those without these conditions (p < 0.01).
Conclusions:
- A statistical association exists between cardiovascular disease and complete edentulism among U.S. adults.
- The cross-sectional design prevents causal inference; further longitudinal research is required.
- Understanding the bidirectional relationship between CVD and edentulism warrants further investigation.
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