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Updated: Jan 17, 2026

An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes
Published on: April 26, 2019
Influence of microbiota composition on the pathogenesis of type 2 diabetes: Physiological aspects
Nataliya V Zharova1, Filipp D Mikhailidi1, Darya A Kabanova1
1FSAEI HE I.M. Sechenov First MSMU of MOH of Russia (Sechenovskiy University), Moscow, Russia.
Abstract:
The development of type 2 diabetes may be influenced by enterotypes and bacterial metabolites. The most important of these are short-chain fatty acids (SCFAs), which play a role in forming the gut-brain axis and in the process of lipogenesis. An increase in lipogenesis can lead to obesity. High levels of adipose tissue in the body trigger chronic inflammation and insulin resistance. This review examines how microbiota composition influences the pathogenesis of type 2 diabetes and the possibility of regulating microbiota through proper nutrition, fecal microbiota transplantation, and prebiotics and probiotics. Additionally, the review notes that an imbalance in the gut microbiota can contribute to diabetes progression and increase cancer risk through inflammatory and immune mechanisms.
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