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Comment on "Fungal-derived chitosan-based hydrogels with antimicrobial properties for infectious wound healing". The
1Department of Kidney Transplantation, Nephropathy Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Abstract:
Zhou et al. (https://doi.org/10.1016/j.carbpol.2025.123917) employed fungal-derived chitosan to synthesize guanidinium-functionalized chitosan (GCS) and aldehyde-modified chitosan (ACS) for Schiff-base hydrogel formation. For completeness, it would be valuable to clarify whether ACS might undergo any self-crosslinking or self-gelation under the conditions used, and to discuss its specific suitability as the aldehyde donor within the Schiff-base network. This comment underscores the importance of a more precise structural definition of ACS, especially concerning its function in the Schiff-base reaction. A thorough structural characterization-ideally via comprehensive NMR analysis-will verify the degree of modification and clarify its exact role in the crosslinking mechanism.
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