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Challenges and opportunities in next-generation LED therapeutic devices.

Chenxi Wang¹, Qiang Yu¹, Ming Li¹

¹Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Light, Science & Applications

|September 14, 2025

Summary

This summary is machine-generated.

Wearable and implantable LED phototherapy devices offer safer, portable alternatives to current treatments. Integrating artificial intelligence (AI) and flexible sensors can create closed-loop systems for advanced home-based phototherapy.

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Area of Science:

Biomedical Engineering
Photomedicine
Materials Science

Background:

Phototherapy provides non-invasive, cost-effective treatment but is limited by bulky, unsafe devices requiring professional operation.
Wearable and implantable LED devices offer improved safety, portability, and uniform light distribution, overcoming current limitations.

Purpose of the Study:

To explore the home-care potential of phototherapy from a clinical perspective.
To provide a comprehensive overview of phototherapy's therapeutic mechanisms and applications.
To identify challenges and propose strategies for wearable and implantable phototherapy devices.

Main Methods:

Synthesizing recent advancements in wearable and implantable phototherapy.
Analyzing clinical challenges and proposing solutions like miniaturization and biocompatibility.
Exploring the integration of artificial intelligence (AI) and flexible sensing technologies.

Main Results:

LED-based devices are promising for next-generation phototherapies, enhancing safety and portability.
Key challenges include miniaturization, biocompatibility, and energy efficiency.
Integrating AI and flexible sensors can establish closed-loop diagnostic and therapeutic systems.

Conclusions:

Wearable and implantable phototherapy holds significant potential for home-based care.
Interdisciplinary research in materials science, flexible electronics, and AI is crucial for advancing phototherapy.
Developing next-generation LED phototherapy devices requires addressing clinical and technological challenges.