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Serum uric acid and male erectile dysfunction: A Mendelian randomization study
Wenyu Chi1, Weihui Jia2, Chengrong Zhang1
1Department of Urology, Affiliated Hospital of Shandong Second Medical University, Weifang, Shandong Province, China.
Medicine
|September 17, 2025
Summary
This study found no causal link between high serum uric acid and erectile dysfunction in men. Therefore, lowering uric acid alone may not treat erectile dysfunction in affected individuals.
Area of Science:
- Urology
- Genetics
- Metabolic Health
Background:
- Elevated serum uric acid levels are common in men.
- Erectile dysfunction affects a significant portion of the male population.
- The potential relationship between serum uric acid and erectile dysfunction requires investigation.
Purpose of the Study:
- To investigate the potential causal relationship between serum uric acid levels and erectile dysfunction in men.
- To determine if genetic predisposition to higher serum uric acid influences erectile dysfunction risk.
Main Methods:
- Mendelian randomization (MR) analysis utilizing genome-wide association study data.
- Two-sample MR design implemented using R software (R Studio 4.3.2, TwoSampleMR package).
- Primary analytical methods included inverse-variance weighted (IVW) and MR-Egger regression.
Main Results:
- The inverse-variance weighted method showed no significant causal association (Beta = 0.068, SE = 0.062, P = 0.274).
- The MR-Egger method also indicated no causal link (Beta = 0.079, SE = 0.101, P = 0.436).
- Results suggest serum uric acid levels do not causally influence erectile dysfunction.
Conclusions:
- This Mendelian randomization study found no evidence of a causal relationship between serum uric acid levels and male erectile dysfunction.
- Current findings suggest that interventions solely targeting uric acid reduction may not be an effective strategy for treating erectile dysfunction in men with hyperuricemia.
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