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Electrogustometry in hemodialysis patients.

G Ralli, G Magliulo, S Persichetti

    Acta Oto-Rhino-Laryngologica Belgica
    |January 1, 1985
    PubMed
    Summary
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    Patients undergoing hemodialysis showed improved taste sensitivity and higher serum zinc levels post-dialysis. These findings suggest potential toxic damage to taste receptors in chronic kidney disease.

    Area of Science:

    • Nephrology
    • Clinical Chemistry
    • Sensory Science

    Background:

    • Chronic kidney disease (CKD) can lead to various complications, including alterations in taste perception.
    • Uremia and altered mineral metabolism are implicated in taste dysfunction in patients with CKD.
    • Hemodialysis is a life-sustaining treatment for end-stage renal disease, but its effects on taste remain an area of investigation.

    Purpose of the Study:

    • To investigate the relationship between serum zinc levels and taste threshold in patients undergoing hemodialysis.
    • To assess the impact of hemodialysis on electrogustometry (taste threshold) and serum zinc concentrations.
    • To explore potential correlations between taste function and zinc status in CKD patients.

    Main Methods:

    • Study included thirty patients undergoing periodic hemodialysis.

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  • Electrogustometry was used to measure taste threshold.
  • Serous (serum) zinc levels were analyzed before and after hemodialysis sessions.
  • Statistical analysis was performed to evaluate changes and correlations.

    • Main Results:

    • A statistically significant improvement in electrogustometric threshold was observed after hemodialysis (p < 0.05).
    • Serum zinc levels were found to be higher after hemodialysis.
    • No significant correlation was found between the electrogustometric threshold and serum zinc levels.

    Conclusions:

    • Hemodialysis may lead to transient improvements in taste sensitivity.
    • Elevated serum zinc levels post-dialysis warrant further investigation.
    • The findings suggest that toxic damage to taste receptors might occur in chronic renal failure, potentially independent of acute zinc level fluctuations.