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Updated: Jan 17, 2026

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation
Published on: August 8, 2025
Upper Extremity Access for Primary Percutaneous Coronary Intervention
Eli Reynolds1, Ivo Bernat2, Sunil V Rao3
1Department of Internal Medicine, New York University Langone Health.
Insights
The radial artery approach significantly reduces bleeding and vascular issues compared to the femoral approach for ST-elevation myocardial infarction patients. This review highlights its benefits while noting potential reperfusion delays.
Area of Science:
- Cardiology
- Vascular Surgery
- Interventional Cardiology
Background:
- Radial access is increasingly favored over femoral access for percutaneous coronary interventions.
- Numerous studies have demonstrated the safety and efficacy of the radial approach.
- Bleeding and vascular complications remain significant concerns in cardiovascular procedures.
Purpose of the Study:
- To review and summarize evidence on radial versus femoral access in ST-elevation myocardial infarction.
- To emphasize the benefits of the radial approach in reducing complications and mortality.
- To provide guidance on implementing transradial primary percutaneous coronary interventions.
Main Methods:
- Systematic review of observational and randomized studies.
- Analysis of data comparing radial and femoral access.
- Evaluation of outcomes including bleeding, vascular complications, and mortality.
Main Results:
- Radial access consistently shows lower rates of bleeding and vascular complications compared to femoral access.
- The radial approach is associated with reduced mortality in ST-elevation myocardial infarction.
- Potential for increased time to reperfusion with radial access was noted.
Conclusions:
- The radial approach is a superior strategy for reducing complications and mortality in ST-elevation myocardial infarction.
- Implementation of transradial primary percutaneous coronary interventions requires careful consideration of workflow.
- Further optimization of transradial techniques can mitigate potential delays in reperfusion.
Abstract:
The reduction in bleeding and vascular complications in radial access compared with femoral access has been repeatedly demonstrated over the past decade of observational and randomized studies. This review summarizes the data and underscores the role of radial approach in reducing bleeding, vascular complications, and mortality in ST-segment elevation myocardial infarction. In addition, the review notes the potential for increased time to reperfusion and provides guidance on implementation of transradial primary percutaneous coronary interventions.
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