Electrochemical Carboxylative Cyclization of Propargylamines with CO2 to Functionalized 2-Oxazolidinones
Zheng-Zheng Meng1, Lan Zhao1, Wen-Jun Xie1
1State Key Laboratory of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin 30007, P. R. China.
Abstract:
The electrochemical conversion of CO2 into value-added chemicals represents a promising strategy for sustainable synthesis. Herein, we report a novel electrochemical carboxylative cyclization of propargylamines with CO2 to access exocyclic iodo-carboxyl-vinylene 2-oxazolidinones bearing two CO2 moieties by using tetraethylammonium iodide (Et4NI) as both the electrolyte and the "iodine source", which enables the one-pot construction of C-O, C-C, C-N, and C-I bonds. The protocol proceeds under mild conditions and accommodates a broad range of substrates, providing access to functionalized 2-oxazolidinones with high structural complexity.
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