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Biomedical Frontiers with PVA-chitosan/lignin@CdZnO multifunctional hydrogel.

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A novel polyvinyl alcohol-chitosan/lignin@CdZnO hydrogel shows potent antibacterial, antioxidant, and wound healing properties. This advanced biomaterial also demonstrated significant anticancer efficacy against breast cancer cells.

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Materials Chemistry

Background:

  • Hydrogels are versatile biomaterials with applications in medicine.
  • Nanoparticle integration enhances hydrogel functionality.
  • Polyvinyl alcohol (PVA), chitosan, and lignin offer unique properties for biomaterial development.

Purpose of the Study:

  • To synthesize and characterize a novel nanoparticle-based hydrogel for biomedical applications.
  • To evaluate the antibacterial, antioxidant, wound healing, and anticancer potential of the developed hydrogel.
  • To confirm the composition and structural integrity of the synthesized hydrogel.

Main Methods:

  • Hydrogel synthesis using polyvinyl alcohol (PVA), chitosan, and lignin-mediated nanocomposites.
  • Characterization via UV-visible spectroscopy, thermal gravimetric analysis, Fourier transform infrared spectroscopy, and XRD.
  • In vitro antibacterial assays against Staphylococcus aureus, Bacillus subtilis, and Escherichia coli.
  • In vitro antioxidant assays (DPPH radical scavenging) and reducing power assays.
  • In vivo wound healing studies on a rat model.
  • In vitro anticancer efficacy assessment against MCF-7 breast cancer cell lines.

Main Results:

  • The PVA-chitosan/lignin@CdZnO hydrogel demonstrated superior bactericidal activity against tested bacterial strains.
  • Antioxidant assays revealed significant DPPH radical scavenging activity (89%) and reducing power.
  • In vivo studies showed accelerated wound closure (91% in 10 days) compared to the control group.
  • The hydrogel exhibited 50% anticancer efficacy against MCF-7 breast cancer cells.
  • Material characterization confirmed the successful synthesis and structural integrity of the nanocomposite hydrogel.

Conclusions:

  • The synthesized PVA-CS/L@CdZnO hydrogel possesses multifunctional biomedical properties.
  • This hydrogel is a promising candidate for antibacterial, antioxidant, wound healing, and anticancer therapies.
  • The findings highlight the potential of lignin-mediated nanocomposites in advanced biomaterial design.