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Updated: Jan 17, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Pyridinium Bromide Perbromide (PyHBr3) Promoted One-Pot Synthesis of Quinoxaline and Aminothiazole Derivatives From
Arabinda Halder1, Shobhondeb Giri1, Sujan Sk2
1Department of Chemistry, Indian Institute of Engineering Science and Technology (IIEST), Shibpur, P.O- Botanic Garden, Howrah, West Bengal, 711103, India.
Abstract:
A straightforward, metal-free synthesis of quinoxaline and aminothiazole derivatives from acetophenone is reported. The reaction was found to be promoted by pyridinium bromide perbromide, a little-explored brominating reagent. A wide variety of substituted quinoxaline and aminothiazole derivatives can be prepared in quantities ranging from milligrams to multi-grams. The use of inexpensive starting materials and reagents makes the method both cost-effective and accessible for large-scale synthesis. Good and consistent yield of the product, operational ease, and environmental benignity make the method more acceptable and applicable in organic synthesis.
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