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Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Updated: Jan 17, 2026

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
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Reporting ADPK Disease Phenotypes on Abdominal Scans.

Zhongxiu Hu1, Elizabeth G Lane1, Grace C Lo1

  • 1Department of Radiology, Weill Cornell Medicine, New York, New York, USA.

Kidney International Reports
|September 22, 2025
PubMed
Summary

Radiology reports for autosomal dominant polycystic kidney disease (ADPKD) often omit kidney and liver volumes, crucial biomarkers. Including these volumes and other key findings in reports will improve clinical utility for ADPKD management.

Keywords:
ADPKDCTMRIclinical studyimagingradiology reports

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Area of Science:

  • Radiology and Medical Imaging
  • Nephrology and Urology
  • Genetics and Genomics

Background:

  • Kidney and liver volumes are vital biomarkers for monitoring autosomal dominant polycystic kidney disease (ADPKD) progression and treatment response, as per KDIGO guidelines.
  • Accurate reporting of these biomarkers in radiological assessments is essential for effective patient management.

Purpose of the Study:

  • To evaluate the frequency of reporting kidney and liver volumes in radiology reports for ADPKD.
  • To assess the reproducibility of kidney volume measurements by radiologists.

Main Methods:

  • Retrospective review of 145 abdominal MRI and CT studies by two independent observers.
  • Discrepancy resolution by two senior radiologists and assessment of interobserver reproducibility for kidney volume measurements.

Main Results:

  • Kidney volumes were reported in only 21% of outside reports, and liver volume in only 1% of relevant examinations.
  • Kidney volume measurements showed a median absolute difference of 15% (ellipsoidal method) and 8% (model-assisted contouring) between outside and study radiologists.
  • Other ADPKD-relevant findings like IVC compression were frequently underreported.

Conclusions:

  • Current radiology reports for ADPKD often lack essential biomarkers like kidney and liver volumes.
  • Improving the inclusion of recommended imaging features in reports can enhance their clinical utility for ADPKD management.