An Overview of Novel Indole Scaffolds with Structural Aspects and Receptor Inhibition for Cancer Treatment

Cancer has consistently posed a concern on a worldwide scale. Numerous studies were conducted to establish the best and most efficient treatment for this illness. We attempted to determine the function and mechanism of indole analogs as molecularly targeted anticancer treatment in this review. These indole analogs target various molecules, influencing the development, growth, and spread of tumors. Target anticancer medications function cytostatically and are typically made to accomplish specific goals, in contrast to traditional chemotherapeutics, which act cytotoxically. Small molecules and macromolecules are a novel class of targeted drugs that resulted from this approach. Certain receptor-targeted drugs are superior to macromolecule medicines in terms of improved patient care. Various receptor inhibitors and tyrosine protein kinase receptors that are currently being targeted by anticancer drugs are studied in this review. The different indole analogs target all of these receptors to identify a successful cancer treatment. The Structural Relationship (SAR) between several indole analogs with anticancer action is also highlighted in the present work.