Multidisciplinary Intervention for Children With Epilepsy and Autism Spectrum Disorder Admitted for EEG: A New

Mary Wojnaroski1, Emily Newton2, Anup D Patel3

  • 1Department of Psychology, Nationwide Children's Hospital, Columbus, OH.

Neurology. Clinical Practice
|September 25, 2025
PubMed

Insights

A new multidisciplinary program successfully enabled children with autism spectrum disorder (ASD) and epilepsy to complete challenging hospital admissions for seizure evaluation. This intervention ensures equitable access to critical care for these vulnerable pediatric patients.

Area of Science:

  • Pediatric Neurology
  • Developmental Pediatrics
  • Quality Improvement Science

Background:

  • Intractable epilepsy affects one-third of children with epilepsy, necessitating Phase 1 hospital admissions for diagnostic evaluations.
  • Children with epilepsy have an increased risk of autism spectrum disorder (ASD), complicating hospital admissions due to developmental delays and behavioral challenges.
  • Challenging behaviors during admission can hinder seizure data collection and treatment planning.

Purpose of the Study:

  • To implement and evaluate a novel, multidisciplinary intervention program for children with ASD and epilepsy undergoing Phase 1 admissions.
  • To increase the participation rate of patients with ASD and epilepsy in a pre-admission treatment program from 0% to 80% within the first year.

Main Methods:

  • A quality improvement (QI) methodology was employed to develop and implement the Phase 1 ASD and epilepsy intervention program.
  • The program involved individualized admission planning, multidisciplinary team communication, and behavioral interventions tailored to each child's needs.
  • Caregiver intake gathered crucial information on the child's development, preferences, and specific needs for admission.

Main Results:

  • The program achieved a sustained centerline shift, with 83.9% (68/81) of enrolled children with ASD and epilepsy successfully completing Phase 1 admissions over five years.
  • Participants ranged in age from 2 to 18 years (mean 10.7), with 70% male and 66.7% White.
  • All participating children completed the multiple-day EEG and all required medical procedures without issue.

Conclusions:

  • The developed multidisciplinary intervention program is feasible and has become standard care for children with ASD and epilepsy at the participating hospital.
  • This program facilitates successful completion of challenging hospital admissions, ensuring equitable access to essential medical care.
  • Similar interventions can be adapted for other hospital admissions or procedures for children with ASD.
Abstract