Related Experiment Video
Updated: Jan 17, 2026

Fluorescence-quenching of a Liposomal-encapsulated Near-infrared Fluorophore as a Tool for In Vivo Optical Imaging
Published on: January 5, 2015
Encapsulation of fucoxanthin in pickering emulsion with improved stability and bioaccessibility for inflammatory
Bowen Jiao1,2, Nanting Zhu2, Decheng Bi2
1State Key Laboratory of Marine Food Processing & Safety Control, Qingdao 266400, China.
Abstract:
Fucoxanthin (FUC), a lipid-soluble carotenoid with various bioactivities, demonstrates promise as a preventive agent against inflammatory bowel disease (IBD). Nevertheless, the inherent instability and low aqueous solubility of FUC limit its application in functional food formulations and pharmaceutical applications. In this study, a FUC-loaded pickering emulsion (G-SPI-COS/FUC emulsion) with high encapsulation efficiency and small particle size was developed by using genipin-crosslinked soy protein isolate (SPI)-chitooligosaccharide (COS) nanoparticles as stabilizers. G-SPI-COS/FUC emulsion exhibited excellent stability under varying pH values, ionic strengths, and storage conditions. In vitro digestion experiments showed that G-SPI-COS/FUC emulsion controlled FUC release and enhanced its intestinal absorption and bioavailability. Furthermore, G-SPI-COS/FUC emulsion was more effective in preventing dextran sulfate sodium (DSS)-induced colitis than free FUC and FUC-loaded pickering emulsion stabilized by native SPI. These findings indicated that G-SPI-COS/FUC emulsion could serve as a promising delivery system for FUC, providing a novel approach to the prevention of IBD.
More Related Videos
06:12Using Multiple Light Scattering to Examine the Stability of Phyllanthus emblica L. Extracts Obtained with Different Extraction Methods
Published on: April 14, 2023
11:28Isolating and Incorporating Light-Harvesting Antennas from Diatom Cyclotella Meneghiniana in Liposomes with Thylakoid Lipids
Published on: August 28, 2018
Related Concept Videos
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Bioavailability Enhancement: Drug Permeability Enhancement
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
Bioavailability Enhancement: Drug Solubility Enhancement