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Linezolid-Associated Lactic Acidosis Triggering a Sepsis Alert: A Case Report
Yusuf Kagzi1, Moni Roy1, Tulika Chatterjee1
1Department of Internal Medicine University of Illinois College of Medicine Peoria Illinois USA.
Clinical Case Reports
|September 25, 2025
Abstract
None:
Elevated lactate alone may trigger false sepsis alerts. In this case, linezolid-induced lactic acidosis mimicked sepsis, triggering automated alerts. Clinicians should consider medication-related causes of lactate elevation and apply clinical context in interpreting automated alerts to avoid unnecessary interventions, alert fatigue, and improve diagnostic accuracy in sepsis management.

