Coexistence of Renal Cell Carcinoma and Psoriasis in Tuberous Sclerosis Complex: A Shared mTOR Pathway Pathogenesis?

Tuberous sclerosis complex (TSC) is a rare multisystem genetic disorder characterized by benign hamartomas in multiple organs. Although renal manifestations such as angiomyolipomas and cysts are common, the occurrence of renal cell carcinoma (RCC) in tuberous sclerosis is rare. Similarly, psoriasis, which is an immune-mediated inflammatory skin disease, is not commonly associated with tuberous sclerosis. We hereby present a 30 year old male patient, a known case of TSC, who presented with extensive plaque psoriasis and was diagnosed with RCC during evaluation. The coexistence of RCC and psoriasis in a patient with tuberous sclerosis might be due to shared mTOR signaling pathway activation, which our study emphasizes.