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Related Experiment Video

Updated: Jan 17, 2026

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
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Modifiable Risk Factors for Hypertensive Disorders in Pregnancy.

Mei-Wei Chang1, Alai Tan1, Joshua M Smyth2

  • 1The Ohio State University College of Nursing.

Critical Public Health
|September 25, 2025
PubMed
Summary
This summary is machine-generated.

Micronutrient intake, including folate and vitamin B12, and psychological distress are linked to hypertensive disorders in pregnancy (HDPs). These associations change throughout pregnancy, highlighting potential areas for intervention.

Keywords:
Folateprenatal depressionprenatal distressstressvitamin B12

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Area of Science:

  • Obstetrics and Gynecology
  • Maternal Health
  • Nutritional Science

Background:

  • Hypertensive disorders in pregnancy (HDPs) are a primary cause of maternal mortality and morbidity worldwide.
  • Understanding contributing factors like micronutrient status and psychological well-being is crucial for improving maternal outcomes.

Purpose of the Study:

  • To investigate the association between micronutrient intake (folate, vitamin B12) and psychological distress (perceived stress, prenatal distress, prenatal depression) with HDPs.
  • To examine how these associations change across different gestational ages.

Main Methods:

  • Longitudinal study collecting data at three time points: ≤17 weeks (T1), 25-27 weeks (T2), and 35-37 weeks gestation (T3).
  • Micronutrient intake (folate, vitamin B12) and psychological distress measures were assessed.
  • T-tests were used to compare participants with and without HDPs.

Main Results:

  • Lower intake of folate and vitamin B12 was associated with HDPs at T1 and T2.
  • Psychological distress showed positive associations with HDPs, with varying strengths across measures and time points: prenatal distress (all T), perceived stress (T3), and prenatal depression (T2, T3).

Conclusions:

  • Both micronutrient status and psychological distress are significantly associated with the development of HDPs.
  • The strength and nature of these associations are dependent on the specific micronutrient or psychological measure and the stage of gestation.