Related Experiment Video
Updated: Jan 16, 2026

A Rat Model of Ventricular Fibrillation and Resuscitation by Conventional Closed-chest Technique
Published on: April 26, 2015
Energy levels in manual defibrillation after prior AED shock
Frans Dammers1, Bas J Verkaik2, Remy Stieglis1
1Amsterdam UMC Location University of Amsterdam, Anesthesiology, Meibergdreef 9, Amsterdam, (the) Netherlands; Amsterdam Public Health, Quality of Care, Amsterdam, (the) Netherlands.
Aim:
European guidelines suggest an escalating defibrillation energy protocol for cases of out-of-hospital cardiac arrest (OHCA) with a shockable rhythm. Our regional manual defibrillators are by default set to deliver 200 J for the initial shock and 360 J for subsequent shocks. In case of a prior AED shock, Emergency Medical Services (EMS) personnel need to deliberately adjust the energy level to 360 J before delivering the first shock with their manual defibrillator to adhere to the escalating energy protocol. We investigated adherence to this escalating energy protocol by EMS and the association with clinical outcomes.
Methods:
Data were collected from the ARREST-registry in (the) Netherlands. We analysed OHCA cases in adults with shockable rhythms who had received at least one shock from an AED and from a manual defibrillator. The primary outcome was the adherence to the escalating energy protocol. Secondary outcomes were the relationships of adherence with various clinical outcomes.
Results:
In 827 cases, adherence to the escalating energy protocol was 20.3 % (95 % CI 17.7 %-23.2 %). No baseline characteristics were significantly associated with increased adherence. Shockable rhythms were terminated by the first manual defibrillator shock in 521/659 (79.1 %) cases with 200 J and 139/168 (82.7 %) cases with 360 J (p = 0.33). Overall 30-day survival rate was 38.4 %. Adherence to protocol was not significantly associated with differences in clinical outcomes after multivariable analyses.
Conclusion:
Adherence to escalating energy protocol by EMS during transition from defibrillation with AED to manual defibrillator is limited. Our data did not provide evidence for a relationship between adherence and clinical outcomes.
Related Concept Videos
Cardiopulmonary Resuscitation III: AED Use
Cardiopulmonary Resuscitation IV: Pharmacological Management
Electrocardiogram Fundamentals
An electrocardiogram (ECG) is a diagnostic tool for identifying cardiac conditions such as arrhythmias, conduction abnormalities, and myocardial ischemia.
Definition
An electrocardiogram (ECG) visualizes the heart's electrical activity by tracing the electrical movement associated with each heartbeat on a graph or monitor. As the heart beats, an electrical wave passes through it, correlating with the cardiac cycle events.
Parts of an ECG
An ECG utilizes electrodes on the skin...
Cardiac Action Potential
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
Cardiopulmonary Resuscitation I: Adult
ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias

