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A rapid pupillometry protocol for clinical use: Effect of age and test-retest repeatability
Jason C Park1, J Jason McAnany1
1University of Illinois Chicago.
Research Square
|September 26, 2025
Summary
This study developed a rapid, portable pupillometry method for clinical use. The new protocol accurately measures pupillary light reflex (PLR) and shows good repeatability across various ages.
Area of Science:
- Ophthalmology
- Neuroscience
- Medical Devices
Background:
- Traditional pupillometry relies on laboratory equipment and lengthy protocols.
- A need exists for rapid, clinically applicable pupillometry methods.
Purpose of the Study:
- To develop and validate a quick, portable pupillometry protocol.
- To assess the clinical utility of a handheld pupillometry device.
Main Methods:
- Evaluated pupillary light reflex (PLR) using a handheld device in 37 healthy adults.
- Determined optimal dark adaptation (DA) time, effect of age, and test-retest repeatability.
- Quantified baseline pupil size (BL), maximum pupil constriction (MPC), and post-illumination pupillary response (PIPR).
Main Results:
- A 3-minute dark adaptation (DA) period was sufficient for maximal pupillary light reflex (PLR) measurements.
- Pupillary light reflex (PLR) measurements showed good test-retest repeatability (approx. 1 mm for BL, 10% for MPC and PIPR).
- Age did not significantly affect baseline pupil size, maximum pupil constriction, or post-illumination pupillary response.
Conclusions:
- The developed portable pupillometry protocol is effective for measuring MPC and PIPR.
- The method demonstrates promising clinical utility due to its portability and short duration (approx. 5 minutes).
